地昔帕明
甩尾试验
化学
伤害
三环
药理学
内科学
医学
抗抑郁药
立体化学
生物化学
受体
海马体
作者
Anders Lund,Arne Tjølsen,Kjell Hole
出处
期刊:Pain
[Ovid Technologies (Wolters Kluwer)]
日期:1989-07-01
卷期号:38 (1): 65-69
被引量:31
标识
DOI:10.1016/0304-3959(89)90074-2
摘要
Tricyclic antidepressants have shown antinociceptive properties in some, but not in all, animal studies using the tail flick test. Tail flick latency has been found to be strongly negatively correlated to tail skin temperature with its highest correlation found when the temperature is measured close to the heated spot. The selective 5-HT reuptake inhibitor zimelidine, as well as the noradrenaline reuptake inhibitor desipramine, increased tail flick latencies. However, this increase could largely be explained by a concomitant reduction in tail skin temperature. The highest dose of desipramine investigated (25 mg/kg) seemed to possess antinociceptive properties in this test also after correction for the fall in tail skin temperature. Lower doses of desipramine (5 and 15 mg/kg) and zimelidine (5, 20 and 30 mg/kg) were either inactive or their effect on tail flick latency could be explained by the fall in tail skin temperature. The apparent antinociceptive effect of zimelidine in the tail flick test thus seems to be due to an effect on tail skin temperature. Desipramine also seems to have its main effect due to a similar mechanism; however, the highest dose of desipramine used induced significant antinociception.
科研通智能强力驱动
Strongly Powered by AbleSci AI