番茄红素
氧化应激
心脏毒性
阿霉素
活性氧
博莱霉素
药理学
抗氧化剂
毒性
化疗
顺铂
化学
化学保护
癌症研究
医学
生物化学
内科学
有机化学
作者
Kazım Şahin,Nurhan Şahin,Ömer Küçük
标识
DOI:10.1080/01635581.2010.509838
摘要
Antineoplastic agents induce the production of free radicals and other reactive oxygen species (ROS) in biological systems. Cytotoxic effects of antineoplastic drugs depend on rapid proliferation of cancer cells. Oxidative stress occurring during chemotherapy may potentially interfere with these effects through reducing the rate of cell proliferation. ROS may also contribute to side effects that occur with chemotherapeutic agents such as doxorubicin-induced cardiotoxicity, cisplatin-induced nephrotoxicity, and bleomycin-induced pulmonary fibrosis. Lycopene is a major carotenoid present in tomatoes, and it is a potent antioxidant that may provide protection against cellular damage caused by ROS. Lycopene may reduce or prevent the side effects of chemotherapy due to its antioxidant and anti-inflammatory properties. This review focuses on the protective effects of lycopene against antineoplastic agent induced toxicity.
科研通智能强力驱动
Strongly Powered by AbleSci AI