加塞乳杆菌
乳酸菌
植物乳杆菌
发酵乳杆菌
嗜酸乳杆菌
生物
体重增加
荟萃分析
益生菌
减肥
肠道菌群
肥胖
脆乳杆菌
重量变化
微生物学
食品科学
体重
医学
内科学
免疫学
内分泌学
细菌
乳酸
发酵
遗传学
作者
Matthieu Million,Emmanouil Angelakis,Mical Paul,Fabrice Armougom,Leonard Leibovici,Didier Raoult
标识
DOI:10.1016/j.micpath.2012.05.007
摘要
Obesity is associated with alteration of the gut microbiota. In order to clarify the effect of Lactobacillus-containing probiotics (LCP) on weight we performed a meta-analysis of clinical studies and experimental models. We intended to assess effects by Lactobacillus species. A broad search with no date or language restriction was performed. We included randomized controlled trials (RCTs) and comparative clinical studies in humans and animals or experimental models assessing the effect of Lactobacillus-containing probiotics on weight. We primarily attempted to extract and use change from baseline values. Data were extracted independently by two authors. Results were pooled by host and by Lactobacillus species and are summarized in a meta-analysis of standardized difference in means (SMDs). We identified and included 17 RCTs in humans, 51 studies on farm animals and 14 experimental models. Lactobacillus acidophilus administration resulted in significant weight gain in humans and in animals (SMD 0.15; 95% confidence intervals 0.05–0.25). Results were consistent in humans and animals. Lactobacillus fermentum and Lactobacillus ingluviei were associated with weight gain in animals. Lactobacillus plantarum was associated with weight loss in animals and Lactobacillus gasseri was associated with weight loss both in obese humans and in animals. Different Lactobacillus species are associated different effects on weight change that are host-specific. Further studies are needed to clarify the role of Lactobacillus species in the human energy harvest and weight regulation. Attention should be drawn to the potential effects of commonly marketed lactobacillus-containing probiotics on weight gain.
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