Local injection of Y-90 glass microspheres under ultrasound guidance for the treatment of liver cancer

Objective:To evaluate the effect of the treatment of liver cancer with Yttrium-90glass microspheres( 90 Y-GTMS)through local injection guided by ultrasound in order to develop a more effective method for liver cancer therapy.Methods:Twenty-two consecutive liver cancer patients with a total of 28tumor nodules were enrolled.Under the guidance of ultrasound,90 Y-GTMS was delivered directly into the target tumor at dosage of 0.5～1.0mci?cm 3 for each lesion depending on its size.Results:Follow-up of the patients at3～60months(average28.4months)after treatment disclosed that9patients were still alive.Up to89.3%(25?28)of tumor focuses treated had their size reduced and3did not changed in size.A post-treated biopsy on12tumor foci showed complete destruction of tumor in9cases.Conclusions:Intralesional local injection with 90 Y-GTMS under guidance of ultrasound is a simple,time saving and safe method for liver cancer treatment,the effect was satisfactory.