Association between cyclooxygenase-2 single nucleotide polymorphism and genetic susceptibility of colorectal adenoma

Objective To investigate the relationship between cyclooxygenase-2(COX-2)single nucleotide polymorphisms(SNP)and the susceptibility of colorectal adenoma(CRA).Methods We used polymerase chain reaction-restricted fragements length polymorphism(PCR-PFLP)and the primer-introduced restriction analysis(PIRA)-PCR assay to genotype the COX-2-765GC、-1195GA、8473TC polymorphisms in a case-control study of 110 CRA cases and 120 adenoma-free controls in Chinese population.Results The distribution of the genotype frequencies of-765GC and-1195GA were not statistically different between the cases and controls(P=0.972 for-765GC and P=0.313 for-1195GA).Polymorphism of COX-2 8473TC were associated with the susceptibility to CRA.Logistic regression analyses revealed that the individuals with the 8473C allele had a decreased risk of CRA(OR=0.500,95%CI:0.274-0.913,P=0.024).Conclusions Polymorphisms of COX-2-765GC and-1195GA are not associated with the susceptibility to CRA.However,COX-2 8473TC can reduce the risk of CRA.