Experimental Studies on Mechanisms of Extracorporeal Thrombus Formation

Thrombus formation is closely related to hydrodynamical conditions. Fresh human blood in healthy donors was used for the experiments. The blood flow in Chandler's ring showed it is a three\|dimensional flow and of secondary conditions. The shear stress on the wall is the maximum. Both curvature of thrombus and blood reflux should be considered for extracorporeal thrombus formation. Results also showed that the cause of thrombus formed in lower menisucs may be the following one: The fluid element at relatively high speed strikes on lower meniscus, which leads to gathering of platelet and red blood cells. When the rotating time of thrombus ring was less than 10min, thrombus did not form well. 15min was the best time for thrombus formation. At rotating speed of 3\^75rpm, thrombus can't come in form.