The Effect of the Low-dose Continuous Infusion of Teli Vasopressin in the Heart and Hemodynamics of the Septic Shock Patients

Objective To explore the effect of the low-dose continuous infusion of teli vasopressin (TP) in the heart and hemodynamics of the septic shock patients.Methods From January 2008 to May 2009,the department of general surgery of the Cinese people’s liberation army 309th Hospital,receive and cure to 245 cases of septic shock patients,of which 25 cases with resisting norepinephrine were treated to low-dose TP 2 mg in 24 hour,with continuous pump intravenous infusion.According to the ultimate survival,the 25 patients were terminal survival state divided into 2 groups:18 patients in the survival group and 7 patients in the death group.Observed two groups patients,before treatment and after treatment on 6,12,24,48 hours,the heart [heart rate (HR),cardiac index (CI)],hemodynamic parameters [pulmonary artery wedge pressure (PAWP),mean arterial pressure (MAP),systemic vascular resistance (SVR)] and norepinephrine doses and other variations.Results Compared with those before of treatment,the survival group and death group were significantly higher MAP after treatment 6 hour,the differences were statistically significant (all P0.05).The CI,PAWP,SVR of two groups were no obvious change with after of treatment at 6,12,24,48 hours,the differences were no significant difference (all P0.05).In the 7 cases of the death group,1 case was died of acute respiratory distress syndrome,6 cases were died of the multiple organ dysfunction.Compared with the death group,the survival group MAP was higher (after of treatment 6 hour),HR was low (after of treatment 12 hour),the maintenance of target MAP (10.0 kPa) required a smaller amount of noradrenaline (after of treatment 24 hour),the differences were statistically significant (all P0.05).Conclusion Low-dose continuous intravenous pump infusion of TP can effectively improve the blood flow in patients with septic shock dynamics,reducing the use of norepinephrine dose,and did not significantly increase cardiac afterload,which can be used as an effective vasopressin,used for the treatment of septic shock.