Objective To investigate the effect and mechanism of compound Preparation of TCM Fumin Gream on skin wound.Methods The back of rabbits was made sterilized wound compared with taking knife wound as model.Make the skin and tissue of wound into sections,then count the number of prosthetic and inflammatory cells and calculate the thickness of granulation tissue.Measure the amount of hydroxyproline.Take down the healing time and the healing ratio of wound.Results Fumin cream could promote the proliferation of macrophage and fibroblastic cells,elevate healing ratio and decurtate the healing time.Conclusion Fumin cream can promote skin wound healing obviously.The mechanisms maybe related to preserving the activity of Prosthetic cells and inflammatory cells,facilitating the growth of granulation tissue.