The determination of drugs and their metabolites is becoming increasingly important in the pharmaceutical and biomedical fields.Capillary electrophoresis(CE) with chemiluminescence detection(CL) has potential application in analytical chemistry due to both the high efficiency of separation of capillary electrophoresis and the high sensitivity of CL detection.The mainly advantages of CE-CL technique include fast separation,less pollution,decreased cost and waste production.The application of the capillary electrophoresis chemiluminescence detection in drug analysis was discussed.