The antimicrobial action of sesamin extracted from sesame was determined by filter paper-disk method and plate culture.The results showed that the antimicrobial action of sesamin was remarkable and the minimal inhibition concentrations(MIC)were 0.1%against bacteria, but antimicrobial action of sesamin against fungi was not obvious. Besides the antioxidation effects of sesamin in soybeansalad oil and peanut oil were studied by peroxide value(POV).The results showed that the antioxidation activity in oil was quite strongsuch as the antioxidation of sesamin in soybean salad oil by adding 0.04%ω(sesamin)was about the same as that of ω(BHT)=0.02%.