Metabolism of Vitamin B6 by Human Subjects with and without Normal Liver Function

Plasma pyridoxal 5′-phosphate (PLP) is below normal for most patients with liver disease? however, they are capable of PLP synthesis and this suggests that administration of pyridoxine (PN) might help normalize their vitamin B6 status. This has been established for patients given 25 mg of pyridoxine/day for 2 weeks both with respect to restoring plasma PLP to the normal range and in repletion of body stores, as reflected in urinary excretion of pyridoxic acid.