Amphotericin B used as a continuous infusion is safer

Many patients in an ICU are intestinal carriers of yeasts with an inherent risk of infections if bowel perforation occurs. Resistance to azoles is increasing, while treatment with conventional amphotericin B (AM-B) is associated with potential toxicity. AM-B given in a continuous 24-hour infusion may be less toxic compared with the conventional 4-hour to 6-hour infusion rate of AM-B [ 1 , 2 ]. AM-B given in a continuous 24-hour infusion is only evaluated in a tertiary care setting, with a predominance of immunocompromised patients. We evaluated the feasibility and safety of continuous AM-B treatment in critically patients with suspected or proven yeast or fungal infections.