Background To explore dynamic trajectories and associations of social vulnerability and physical frailty with aging in China and the UK. Methods Data were from CHARLS and ELSA. Participants were age ≥60 years with non-frail at baseline. Cumulative deficit approach was for social vulnerability and physical frailty. Group-based trajectory modeling identified their trajectories. Cox proportional hazard and logistic regression models estimated associations between them, with sensitivity analyses. Restricted cubic splines visualized the dose-response relationship. Results UK sample older adults exhibited lower social vulnerability and physical frailty than their Chinese counterparts. Per 0.1-point increase in social vulnerability index, physical frailty risk increased by 29% in China (HR=1.29[1.20-1.37]) and 35% in the UK (HR=1.35, [1.25-1.47]). Odds of older adults being categorized into the low-robustness fast-growth group increased to 1.42 times in China (OR=1.42[1.30-1.55]) and 1.49 times in the UK (OR=1.49[1.37-1.63]). Compared with the low-vulnerability group, the high-vulnerability increasing group had 84% higher physical frailty risk in China (HR=1.84[1.60-2.12]) and 85% higher in the UK (HR=1.85[1.54-2.23]). The odds of individuals in the high-vulnerability increasing group being classified into the low-robustness fast-growth group increased 2.06 times in China (OR=2.06[1.73-2.46]) and 2.09 times higher in the UK (OR=2.09[1.73-2.51]). China had a non-linear social vulnerability-physical frailty association with a sharp increase at a threshold of 0.47, while the UK had a linear one. Conclusions Individuals with increasing social vulnerability over time had a higher physical frailty risk, particularly in lower-welfare countries. Improving self-efficacy and life control may benefit older adults regarding social vulnerability and physical frailty.