A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolylcarbamates

An efficient and convenient substitution protocol was developed for the synthesis of novel benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethylphosphoramide (HMPA) and t-BuLi medium at -78°C to room temperature. The reactions were monitored with TLC for about 3-4 h. The yields obtained were also considerably good. Keywords: α-amido sulphones, benzyl (imidazolyl) (aryl) methyl carbamate, Hexamethylphosphoramide, t-BuLi, imidazole, imidazolyl carbamate.