重组DNA
计算生物学
信号肽
功能(生物学)
生物
细胞生物学
分泌物
分泌蛋白
生物化学
基因
作者
Hajar Owji,Navid Nezafat,Manica Negahdaripour,Ali Hajiebrahimi,Younes Ghasemi
标识
DOI:10.1016/j.ejcb.2018.06.003
摘要
Signal peptides (SP) are short peptides located in the N-terminal of proteins, carrying information for protein secretion. They are ubiquitous to all prokaryotes and eukaryotes. SPs have been of special interest in several scientific and industrial fields, including recombinant protein production, disease diagnosis, immunization, and laboratory techniques. Recently, the role of SPs in recombinant protein production has gained too much attention. Herein, several studies have been reviewed to elucidate the precise structure and function of SPs, particularly the optimized ones for recombinant protein production. However, some features of SPs still have remained obscure. In this review, some approaches concerning elucidation and optimization of SPs are discussed, and pragmatic conclusions and suggestions for future studies are also proposed. Moreover, a summary of secretory pathways, evolutionary changes, functions, applications, and different types of SPs is mentioned. At last, current limitations and prospects are discussed.
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