铱
化学
立体中心
催化作用
均三甲苯
脱氢
分子内力
烷基
药物化学
配体(生物化学)
还原消去
有机化学
对映选择合成
生物化学
受体
作者
Toshimichi Ohmura,Kaito Yagi,Satoshi Kusaka,Michinori Suginome
标识
DOI:10.1021/acscatal.9b05579
摘要
In the presence of an iridium catalyst bearing DTBM-SEGPHOS as a ligand and tert-butylethylene as a hydrogen scavenger, 2-ethyl-N-methylanilines were converted directly to 3-methylindoles in high yields. The reaction proceeded efficiently in mesitylene at 150 °C through transfer dehydrogenation of the ethyl group and following intramolecular dehydrogenative C–H/C–H coupling of the N-methyl group with the vinyl group formed in situ. The iridium catalyst system was applied to the asymmetric conversion affording enantioenriched indolines bearing a quaternary stereogenic carbon center at the C3 position.
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