肝细胞癌
乙型肝炎病毒
表观遗传学
病毒
DNA损伤
癌症研究
氧化应激
DNA病毒
生物
免疫学
医学
DNA修复
肝细胞
病毒学
DNA
内科学
遗传学
基因
基因组
作者
Ji-Young Lee,Kuen-Nan Tsai,Jing-hsiung James Ou
出处
期刊:Recent results in cancer research
日期:2021-01-01
卷期号:: 47-70
被引量:4
标识
DOI:10.1007/978-3-030-57362-1_3
摘要
Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). There are approximately 250 million people in the world that are chronically infected by this virus, resulting in nearly 1 million deaths every year. Many of these patients die from severe liver diseases, including HCC. HBV may induce HCC through the induction of chronic liver inflammation, which can cause oxidative stress and DNA damage. However, many studies also indicated that HBV could induce HCC via the alteration of hepatocellular physiology that may involve genetic and epigenetic changes of the host DNA, the alteration of cellular signaling pathways, and the inhibition of DNA repair mechanisms. This alteration of cellular physiology can lead to the accumulation of DNA damages and the promotion of cell cycles and predispose hepatocytes to oncogenic transformation.
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