连接器
药物输送
聚合物
结合
药品
部分
纳米技术
组合化学
免疫原性
智能聚合物
天然聚合物
毒品携带者
化学
材料科学
计算机科学
药理学
有机化学
医学
数学
免疫学
数学分析
操作系统
免疫系统
作者
Pradip Thakor,Valamla Bhavana,Ravi Kumar Sharma,Saurabh Srivastava,Shashi Bala Singh,Neelesh Kumar Mehra
标识
DOI:10.1016/j.drudis.2020.06.028
摘要
Polymer–drug conjugates (PDC) have exhibited clinical and commercial success in the field of drug delivery. A polymeric backbone, linker, targeting moiety, and drug constitute the building blocks of PDCs. Current attention is focusing on natural polymeric carriers, in particular the concept of graft copolymers, such as a combination of polymers and polysaccharides, to explore dual benefits such as combined vehicles and targeting moieties. Polymer heterogeneity, synthesis of PDCs, broad molecular weight distribution, conjugate variability, immunogenicity of polymers, safety, stability, and stringent regulatory approval are the major obstacles to the successful transition of PDCs to the clinic. In this review, we discuss natural and synthetic PDCs combined with computational modeling for diverse pharmaceutical and biomedical applications.
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