生物膜
群体感应
流出
微生物学
抗生素耐药性
细菌
抗生素
抗菌剂
胞外聚合物
生物
抗药性
化学
生物化学
遗传学
作者
Shivani Singh,Saptashwa Datta,Kannan Badri Narayanan,K. Narayanan Rajnish
标识
DOI:10.1186/s43141-021-00242-y
摘要
Bacterial biofilms are aggregation or collection of different bacterial cells which are covered by self-produced extracellular matrix and are attached to a substratum. Generally, under stress or in unfavorable conditions, free planktonic bacteria transform themselves into bacterial biofilms and become sessile.Various mechanisms involving interaction between antimicrobial and biofilm matrix components, reduced growth rates, and genes conferring antibiotic resistance have been described to contribute to enhanced resistance. Quorum sensing and multi-drug resistance efflux pumps are known to regulate the internal environment within the biofilm as well as biofilm formation; they also protect cells from antibiotic attack or immune attacks. This review summarizes data supporting the importance of exopolysaccharides during biofilm formation and its role in antibiotic resistance.Involvement of quorum sensing and efflux pumps in antibiotic resistance in association with exopolysaccharides. Also, strategies to overcome or attack biofilms are provided.
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