Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale

Abstract Three previously undescribed chlorophenyl glycosides, (2,4,6‐trichloro‐3‐hydroxy‐5‐methoxyphenyl)methyl β‐D‐glucopyranoside ( 1 ), (2,4‐dichloro‐3,5‐dimethoxyphenyl)methyl 6‐ O ‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside ( 2 ) and 4‐chloro‐3‐methoxy‐5‐methylphenyl 6‐ O ‐(6‐deoxy‐β‐L‐mannopyranosyl)‐β‐D‐glucopyranoside ( 3 ) were obtained from Lilium regale . The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2,4‐dichloro‐3,5‐dimethoxyphenyl)methyl 6‐ O ‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside ( 2 ) can inhibit the proliferation of lung carcinoma A549 cells with an IC 50 value of 29 μΜ.