Retrosynthetic polyketide disconnections for unnatural aromatics

Polyketide synthases are extraordinarily complex enzymatic machineries that govern the assembly and cyclization of poly-β-carbonyl intermediates to an enormous diversity of natural products. Captivatingly, this biosynthetic strategy is transferable to the retrosynthetic analysis of unnatural aromatics, enabling strategic biomimetic polyketide cyclizations to design an extensive range of otherwise unrelated aromatic products.