化学
串联
羟醛反应
级联反应
级联
序列(生物学)
组合化学
离子
立体化学
作者
Anilkumar Gunnam,Alagesan Balasubramani,Goverdhan Mehta
标识
DOI:10.1021/acs.joc.2c00057
摘要
Recursive anion-mediated activation of o-bis-ynones sets off a Michael addition-aldol reaction-dehydrative rearrangement cascade, leading to the one-pot synthesis of 1-indenones via orthogonal interplay between the two ortho-ynone moieties. Repeating the recursive anion engagement with the 1-indenones unfolded access to a functionally embellished cyclopenta[a]inden-8(2H)-one core and its spiroannulated analogues either directly or stepwise through tandem 1,6-Michael-type addition-6π electrocyclization and an in situ oxidation sequence.
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