Silk Microneedle Patch Capable of On‐Demand Multidrug Delivery to the Brain for Glioblastoma Treatment (Adv. Mater. 1/2022)

Tumor Therapy In article number 2106606, Nan Qin, Tiger H. Tao, and co-workers report a heterogenous silk microneedle patch to spatiotemporally and sequentially deliver multiple therapeutic drugs for hemostasis, anti-angiogenesis, and apoptosis of brain tumor cells. Drug release kinetics are well-defined by tuning the crosslinking degree of the silk and applying a trigger of transcranial NIR-light irradiation. This biodegradable patch has potential applications for the clinical treatment of intracranial tumors.