Foreign body reaction three years after injection with polycaprolactone (Ellanse®)

Filler injections are commonly performed for facial rejuvenation and volume replacement. Injectable polycaprolactone (PCL) derivatives are widely used as soft tissue fillers for aesthetic facial enhancement. PCL is a synthetic linear polyester with almost 50% crystallinity, and consists of 6-hydroxyhexanoates. PCL is a soft dermal filler based on PCL microspheres (range: 25-50 μm); it is non-toxic and biodegradable, and is completely excreted from the human body in two stages. The first stage starts [...]