蛋氨酸
FGF21型
胰岛素抵抗
磷酸戊糖途径
氧化应激
热卡限制
生物
营养感应
自噬
糖尿病
碳水化合物代谢
内分泌学
医学
内科学
生物化学
新陈代谢
成纤维细胞生长因子
糖酵解
氨基酸
信号转导
受体
细胞凋亡
作者
Jie Yin,Wenkai Ren,Shuai Chen,Yuying Li,Hui Han,Jing Gao,Gang Liu,Xin Wu,Tiejun Li,Sung Woo Kim,Yulong Yin
标识
DOI:10.1002/mnfr.201700951
摘要
Abstract Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction (MR) and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.
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