This chapter contains sections titled: Introduction The Shape of the Four-Membered Ring Reason for Puckering of the Cyclobutane Ring Monosubstituted Cyclobutanes Disubstituted Cyclobutanes Tetrasubstituted Cyclobutanes Cyclobutane as a Member of a Simple Fused Ring System 1,3-Disubstituted Systems in Which the Cyclobutane Is Part of a Bridged Polycyclic System The Cyclobutyl Carbocation Heterocyclic Four-Membered Ring Derivatives