钯
动力学分辨率
催化作用
化学
选择性
位阻效应
组合化学
光学活性
手性助剂
瞬态(计算机编程)
对映选择合成
有机化学
计算机科学
操作系统
作者
Qi‐Jun Yao,Shuo Zhang,Bei‐Bei Zhan,Bing‐Feng Shi
标识
DOI:10.1002/anie.201701849
摘要
Abstract Atroposelective synthesis of axially chiral biaryls by palladium‐catalyzed C−H olefination, using tert ‐leucine as an inexpensive, catalytic, and transient chiral auxiliary, has been realized. This strategy provides a highly efficient and straightforward access to a broad range of enantioenriched biaryls in good yields (up to 98 %) with excellent enantioselectivities (95 to >99 % ee ). Kinetic resolution of trisubstituted biaryls bearing sterically more demanding substituents is also operative, thus furnishing the optically active olefinated products with excellent selectivity (95 to >99 % ee , s ‐factor up to 600).
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