去铁胺
血管生成
伤口愈合
富血小板血浆
药理学
炎症
生物材料
生物医学工程
医学
血小板
化学
癌症研究
免疫学
外科
生物化学
作者
Jiao Zhang,Qian Luo,Qian Hu,Tiantian Zhang,Jingyu Shi,Li Kong,Dehao Fu,Conglian Yang,Zhiping Zhang
标识
DOI:10.1016/j.apsb.2022.11.006
摘要
Delayed diabetic wound healing has placed an enormous burden on society. The key factors limiting wound healing include unresolved inflammation and impaired angiogenesis. Platelet-rich plasma (PRP) gel, a popular biomaterial in the field of regeneration, has limited applications due to its non-injectable properties and rapid release and degradation of growth factors. Here, we prepared an injectable hydrogel (DPLG) based on PRP and laponite by a simple one-step mixing method. Taking advantages of the non-covalent interactions, DPLG could overcome the limitations of PRP gels, which is injectable to fill irregular injures and could serve as a local drug reservoir to achieve the sustained release of growth factors in PRP and deferoxamine (an angiogenesis promoter). DPLG has an excellent ability in accelerating wound healing by promoting macrophage polarization and angiogenesis in a full-thickness skin defect model in type I diabetic rats and normal rats. Taken together, this study may provide the ingenious and simple bioactive wound dressing with a superior ability to promote wound healing.
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