Nonlesional Skin and Blood Interferon Scores Among Patients With a History of Cutaneous Lupus

This cross-sectional study found that ISGs, as represented by IFN scores, in nonlesional skin and PBMCs were elevated in patients with lupus with a history of CLE compared with patients without CLE, suggesting that patients with lupus with and without CLE comprise 2 endotypes, with stronger IFN dysregulation occurring in patients with CLE.