化学
催化作用
胺化
芳基
轴手性
手性(物理)
对映选择合成
组合化学
有机化学
药物化学
立体化学
手征对称性
烷基
物理
量子力学
夸克
Nambu–Jona Lasinio模型
作者
Subhas Chandra Pan,Chandrakanta Parida,Siddharth K. Dave,Kousik Das
标识
DOI:10.1002/adsc.202300080
摘要
Abstract Herein we disclose a catalytic asymmetric dearomatization reaction of β‐ naphthols with 4‐aryl‐1,2,4‐triazole‐3,5‐diones. A chiral phosphoric acid with spiro motif was found to be effective for this reaction. The chiral urazole embedded naphthalenones having both axial and central chirality were obtained in good to high yields (70–85%) with high diastereo‐ and enantioselectivities (>20:1, 8–96% ees), having C−N rotational energy barrier 31.54 K.Cal.mol −1 and t 1/2 25 °C=589.8 years. The scope of the reaction was broad and few applications including a bromo‐amination reaction have been demonstrated. magnified image
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