A Study of Localized Spontaneous Activity Changes in Cerebral White Matter in Adolescent Smoking Addiction

This study reveals abnormal patterns of localized spontaneous neural activity in the white matter of young smokers. Given the developmental trajectory of the brain, alterations in white matter functional activity may precede those in gray matter. These findings suggest that localized white matter functional changes could serve as early biomarkers of young nicotine addicts and expand our understanding of its underlying neurobiological mechanisms.