Recent Advances in Plant‐Based Vaccines: From Molecular Farming Innovations to Global Health Applications

ABSTRACT Vaccines are pivotal in mitigating infectious diseases by reducing infection rates, severity, and mortality. Plant‐derived vaccines—engineered to express antigens in plants, offer distinctive advantages, including cost‐efficient production, enhanced biosafety profiles, superior thermal stability, and simplified logistics. Recent advances in plant biotechnology have enabled the large‐scale production of plant‐based vaccines, positioning them as a viable and transformative alternative to conventional vaccine platforms. This review synthesizes the latest advances, identifies key challenges, and explores future directions in plant‐based vaccine development. By highlighting the transformative potential of plant biotechnology in vaccine manufacturing, this work underscores the critical role of plant biology in advancing global health.