Rh(III)-Catalyzed Direct C–H Cyclization of N-Nitrosoanilines with 1,3-Dicarbonyl Compounds: A Route to Tetrahydrocarbazol-4-ones

A novel and efficient Rh(III)-catalyzed direct C-H bond tandem annulation of N-nitrosoanilines with 1,3-dicarbonyl compounds through two C-H bond cleavage was developed. This protocol provides a rapid access to a series of valuable tetrahydrocarbazol-4-ones with the feature of readily available starting materials, broad functional group tolerance, and in situ generation of carbene precursors. Importantly, some reaction products exhibited promising antiproliferative activity in cancer cell lines.