An Encoding Scheme to Enlarge Practical DNA Storage Capacity by Reducing Primer-Payload Collisions

Deoxyribonucleic Acid (DNA), with its ultra-high storage density and long durability, is a promising long-term archival storage medium and is attracting much attention today. A DNA storage system encodes and stores digital data with synthetic DNA sequences and decodes DNA sequences back to digital data via sequencing. Many encoding schemes have been proposed to enlarge DNA storage capacity by increasing DNA encoding density. However, only increasing encoding density is insufficient because enhancing DNA storage capacity is a multifaceted problem.