鲁米诺
电化学发光
化学
过氧化氢
激进的
光化学
活性氧
氢氧化物
无机化学
电化学
氧气
化学发光
超氧化物
检出限
电极
有机化学
色谱法
生物化学
物理化学
酶
作者
Mengzhen Xi,Zhichao Wu,Zhen Luo,Ling Ling,Weiqing Xu,Runshi Xiao,Hengjia Wang,Qie Fang,Lili Hu,Wenling Gu,Chengzhou Zhu
标识
DOI:10.1002/anie.202302166
摘要
Abstract In conventional luminol electrochemiluminescence (ECL) systems, hydrogen peroxide and dissolved oxygen are employed as typical co‐reactants to produce reactive oxygen species (ROS) for efficient ECL emission. However, the self‐decomposition of hydrogen peroxide and limited solubility of oxygen in water inevitably restrict the detection accuracy and luminous efficiency of luminol ECL system. Inspired by ROS‐mediated ECL mechanism, for the first time, we used cobalt‐iron layered double hydroxide as co‐reaction accelerator to efficiently activate water to generate ROS for enhancing luminol emission. Experimental investigations verify the formation of hydroxyl and superoxide radicals in the process of electrochemical water oxidation, which subsequently react with luminol anion radicals to trigger strong ECL signals. Finally, the detection of alkaline phosphatase has been successfully achieved with impressive sensitivity and reproducibility for practical sample analysis.
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