Internet of Things for Diagnosis of Alzheimer’s Disease: A Multimodal Machine Learning Approach Based on Eye Movement Features

Alzheimer's disease (AD) is a degenerative neurological disease that occurs in the elderly with typical symptoms of decline in cognition, manifested by eye movement behaviors. The key to AD treatment requires early detection of cognitive impairment, which relies on frequent medical screening. This article proposes an Internet of Things (IoT) architecture constructed with eye-tracker (ET) nodes and cloud-based diagnosis enabled by machine learning (ML), which can provide convenient screening of oculomotor abnormalities and automatic identification of early-stage AD. The bespoke ET nodes collect 3-D oculomotor responses from diverse stereo video stimulation trials and transmit data into a dedicated multimodal ML (MMML) algorithm in the cloud. The algorithm incorporates multimodal features extracted from diverse oculomotor types to enhance the classification accuracy and optimized data dimension reduction in feature fusion to improve the classifier's performance. From evaluation, the proposed method can distinguish AD patients from the control group with 86% accuracy (ACC), 78% true positive rate (TPR), and 90% positive predictive value (PPV). The results confirm the effectiveness of our MMML algorithm in AD diagnosis with the fusion of multimodal oculomotor features and prove the feasibility of our IoT-powered eye-tracking solution for AD screening.