化学
三氟甲基
组合化学
芳基
三唑
微波辐射
催化作用
分子内力
亲核细胞
1,2,4-三唑
亲核加成
二硫化碳
有机化学
烷基
作者
Najmeh Zeinali,Ali Darehkordi
标识
DOI:10.1016/j.tetlet.2023.154727
摘要
Herein, a fast, simple, efficient, and eco-friendly procedure for the synthesis of 4-aryl-3-(trifluoromethyl)-1H-1,2,4-triazole-5(4H)-thiones under microwave irradiation is introduced. The current strategy enabled the synthesis of triazole-5(4H)-thiones scaffolds at 70 °C under shorter reaction times through the sequential nucleophilic addition and then intramolecular ring closing reactions between trifluoromethyl arylacetimidohydrazides and carbon disulfide in high yields.
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