平面的
晶体管
材料科学
电解质
细胞内
纳米线
纳米技术
光电子学
场效应晶体管
噪音(视频)
生物医学工程
计算机科学
电压
电极
电气工程
化学
医学
生物化学
计算机图形学(图像)
图像(数学)
物理化学
人工智能
工程类
作者
Adrica Kyndiah,Michele Dipalo,Alireza Molazemhosseini,Fabrizio Antonio Viola,Francesco Modena,Giuseppina Iachetta,Nicolas Zorn,Željko Popović,Goran Stojanović,Jana Zaumseil,Francesco De Angelis,Mario Caironi
标识
DOI:10.1109/fleps57599.2023.10220365
摘要
Minimally invasive recording of intracellular action potentials in electrogenic cells is in high demand. Present tools and technology include invasive patch clamp technique, 3D nanostructures often combined with electro/opto poration methods and nanodevices such as nanowire field-effect transistors. However, these approaches mostly require complex manufacturing processes or are invasive. With the aim of enabling a cost-effective, non-invasive recording platform based on devices that can be easily fabricated and processed from solution with large-area printing techniques, we propose planar Electrolyte Gated Field-Effect Transistors (EGFETs) based on solution-processed carbon based material. Remarkably, despite the planar geometry of the device, we could demonstrate the spontaneous recording of intracellular action potentials of human induced pluripotent stem cells derived cardiomyocytes. The simplicity of the device combined with the high signal to noise ratio opens up new opportunities for low-cost, reliable, and flexible biosensors and arrays for high quality parallel recording of cellular action potentials.
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