纳米凝胶
药物输送
纳米技术
材料科学
正电子发射断层摄影术
生物相容性材料
体内
单光子发射计算机断层摄影术
组合化学
生物医学工程
化学
医学
核医学
生物
生物技术
作者
Manja Kubeil,Yota Suzuki,Maria Antonietta Casulli,Rozy Kamal,Takeshi Hashimoto,Michael Bachmann,Takashi Hayashita,Holger Stephan
标识
DOI:10.1002/adhm.202301404
摘要
Nanogels open up access to a wide range of applications and offer among others hopeful approaches for use in the field of biomedicine. This review provides a brief overview of current developments of nanogels in general, particularly in the fields of drug delivery, therapeutic applications, tissue engineering, and sensor systems. Specifically, cyclodextrin (CD)-based nanogels are important because they have exceptional complexation properties and are highly biocompatible. Nanogels as a whole and CD-based nanogels in particular can be customized in a wide range of sizes and equipped with a desired surface charge as well as containing additional molecules inside and outside, such as dyes, solubility-mediating groups or even biological vector molecules for pharmaceutical targeting. Currently, biological investigations are mainly carried out in vitro, but more and more in vivo applications are gaining importance. Modern molecular imaging methods are increasingly being used for the latter. Due to an extremely high sensitivity and the possibility of obtaining quantitative data on pharmacokinetic and pharmacodynamic properties, nuclear methods such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) using radiolabeled compounds are particularly suitable here. The use of radiolabeled nanogels for imaging, but also for therapy, is being discussed.
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