有机溶剂
自愈水凝胶
木质素
化学
反应性(心理学)
肿胀 的
药物输送
聚合物
化学改性
化学结构
高分子化学
有机化学
化学工程
病理
替代医学
工程类
医学
作者
Amaia Morales,Jalel Labidi,Patricia Gullón
标识
DOI:10.1016/j.susmat.2022.e00474
摘要
So far, the possibility of synthesizing hydrogels based on multiple biopolymers has been investigated, and among them lignin has proven to be one of the potentials for this purpose due to the multiple advantages it offers. However, because of its high molecular weight, steric hindrance and few reactive sites on its structure, it is sometimes necessary to improve its reactivity though chemical modifications. On the basis of previous results, two chemical modifications were selected in order to enhance almond, walnut and commercial alkaline and organosolv lignins' reactivity: a peroxidation reaction for alkaline ones and a hydroxymethylation for organosolv ones. Both reactions were confirmed by multiple techniques (i.e. FTIR, GPC and TGA). Hydrogels were synthesized from these lignins according to previous works. The high lignin waste of the synthesized hydrogels suggested that despite the modification of the lignins, just the highest molecular weight fractions reacted with the matrix polymer. Moreover, the swelling capacity of modified alkaline lignin-based hydrogels was negatively affected, whereas the one for organosolv lignin-based samples improved. The SEM micrographs explained the aforementioned, and the results from the DSC and compression tests were in accordance with them. Self-extracted quercetin loading and release studies suggested that these samples could be used for controlled drug delivery.
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