KIO3-catalyzed selective oxidation of thiols to disulfides in water under ambient conditions
化学
催化作用
环境化学
无机化学
有机化学
作者
Jorge Pedro Sousa,Marcelo S. Franco,Leila Dorácio Mendes,Laureane Almeida Santiago de Araújo,Vanessa B. dos Santos,José S. S. Neto,Tiago Elias Allievi Frizon,Eduardo Carasek,Sumbal Saba,Jamal Rafique,Antônio L. Braga
Herein, we report a KIO3-catalyzed oxidative coupling of thiols to their corresponding disulfides in water, in a short time and at ambient temperature. The reaction has a broad scope and exhibits good functional group tolerance, resulting in the desired products in excellent yields. This approach allows the reuse of the reaction system in multiple cycles and scale-up. Furthermore, the current protocol demonstrates compatibility for in situ generation of disulfides and post application in C(sp2)-H bond sulfenylation.