Midnolin‐proteasome pathway for protein degradation

Overexpression of immediate-early genes (IEGs) has been linked to was associated with cancer progression and prognosis. In a recent study, Gu et al. reported the midnolin-proteasome pathway, a novel ubiquitin-independent proteasomal degradation. 1 The study provided the mechanism of rapid degradation for nuclear proteins with high unsteadiness. Targeting the midnolin-proteasome pathway might be beneficial for cancer therapy.