沸石咪唑盐骨架
药物输送
纳米技术
癌症免疫疗法
免疫疗法
咪唑酯
纳米医学
纳米颗粒
癌症
癌症治疗
材料科学
癌症治疗
医学
金属有机骨架
化学
内科学
无机化学
有机化学
吸附
作者
Farangis Rastin,Mahsa Akbari Oryani,Sonia Iranpour,Hossein Javid,Alireza Hashemzadeh,Mehdi Karimi‐Shahri
摘要
This review delves into the potential of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles in augmenting the efficacy of cancer immunotherapy, with a special focus on the delivery of programmed cell death receptor 1 (PD-1) inhibitors. The multifunctional nature of ZIF-8 nanoparticles as drug carriers is emphasized, with their ability to encapsulate a range of therapeutic agents, including PD-1 inhibitors, and facilitate their targeted delivery to tumor locations. By manipulating the pore size and surface characteristics of ZIF-8 nanoparticles, controlled drug release can be realized. The strategic use of ZIF-8 nanoparticles to deliver PD-1 inhibitors presents a precise and targeted modality for cancer treatment, reducing off-target impacts and enhancing therapeutic effectiveness. This combined strategy addresses the existing challenges and constraints of current immunotherapy techniques, with the ultimate goal of enhancing patient outcomes in cancer therapy.
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