牙本质形成
牙本质
牙髓(牙)
抗菌剂
牙髓炎
牙髓干细胞
细胞外基质
细胞生物学
体内
牙科
药理学
化学
体外
成牙本质细胞
医学
生物
生物化学
生物技术
有机化学
作者
Zhi jian Xie,Wentao Jiang,Hui Liu,Lingling Chen,Chengkai Xuan,Zhenxing Wang,Xuetao Shi,Zhengmei Lin,Xianling Gao
标识
DOI:10.1002/adhm.202303709
摘要
The preservation of vital pulps is crucial for maintaining the physiological functions of teeth; however, vital pulp therapy (VPT) of pulpitis teeth remains a substantial challenge due to uncontrolled infection, excessive inflammation, and limited regenerative potential. Current pulp capping agents have restricted effects in the infectious and inflammatory microenvironment. To address this, a multifunctional hydrogel (TGH/DM) with antibacterial, immunomodulatory, and mineralization-promoting effects is designed. The antimicrobial peptide (AMP) and demineralized dentin matrix are incorporated into the hydrogel, achieving sustainable delivery of AMP and a cocktail of growth factors. In vitro results show that TGH/DM could kill endodontic microbiota, ameliorate inflammatory responses of human dental pulp stem cells (hDPSCs), and prompt odontogenic differentiation of inflammatory hDPSCs via activation of peroxisome proliferator-activated receptor gamma. In vivo results suggest that TGH/DM is capable of inducing M2 phenotype transformation of macrophages in mice and fostering the regeneration of the dentin-pulp complex in inflamed pulps of beagle dogs. Overall, this study first proposes the synergistic regulation of AMP and tissue-specific extracellular matrix for the treatment of pulpitis, and the advanced hydrogel provides a facile and effective way for VPT.
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