表观遗传学
染色质
血管平滑肌
瑞士/瑞士法郎
生物
细胞生物学
神经科学
平滑肌
基因
生物信息学
染色质重塑
遗传学
内分泌学
作者
Hongyu Liu,Yang Zhao,Guizhen Zhao,Yongjie Deng,Y. Eugene Chen,Jifeng Zhang
出处
期刊:Cells
[MDPI AG]
日期:2024-01-16
卷期号:13 (2): 168-168
标识
DOI:10.3390/cells13020168
摘要
Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal role in orchestrating chromatin conformation, which is critical for gene regulation. In this review, we provide a summary of research related to the involvement of the SWI/SNF complexes in VSMC and cardiovascular diseases (CVD), integrating these discoveries into the current landscape of epigenetic and transcriptional regulation in VSMC. These novel discoveries shed light on our understanding of VSMC biology and pave the way for developing innovative therapeutic strategies in CVD treatment.
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