Stereoselective Syntheses of the C1-C5, C7-C15 and C17-C24 Fragments of (+)-Discodermolide Using a Catalytic and Asymmetric Vinylogous Mukaiyama Reaction

The stereoselective syntheses of C1-C5, C7-C15 and C17-C24 fragments of (+)-discodermolide are described from a common intermediate: an α,β-unsaturated six-membered lactone obtained in one step using a catalytic and asymmetric vinylogous Mukaiyama (CAVM) reaction.