Time-resolved transmittance for the noninvasive determination of tissue optical properties

Time-resolved measurements of femtosecond light pulses transmitted through turbid biological media were performed to determine the optical absorption and scattering coefficients. A simple model based on the time-dependent diffusion equation allows us to calculate analytical expressions for the spatially-integrated time-resolved transmittance in terms of the interaction coefficients of the tissue slab. We derived the optical coefficients by fitting the diffusion solution to the experimental data of the spatially integrated time-resolved diffuse transmittance for different boundary conditions at the turbid medium-air interface.