凝聚
微流控
化学
水溶液
色散(光学)
纳米技术
化学工程
材料科学
色谱法
有机化学
光学
物理
工程类
作者
Dirk van Swaay,T-Y Dora Tang,Stephen Mann,Andrew J. de Mello
标识
DOI:10.1002/anie.201502886
摘要
Abstract We report on the formation of coacervate droplets from poly(diallyldimethylammonium chloride) with either adenosine triphosphate or carboxymethyl‐dextran using a microfluidic flow‐focusing system. The formed droplets exhibit improved stability and narrower size distributions for both coacervate compositions when compared to the conventional vortex dispersion techniques. We also demonstrate the use of two parallel flow‐focusing channels for the simultaneous formation and co‐location of two distinct populations of coacervate droplets containing different DNA oligonucleotides, and that the populations can coexist in close proximity up to 48 h without detectable exchange of genetic information. Our results show that the observed improvements in droplet stability and size distribution may be scaled with ease. In addition, the ability to encapsulate different materials into coacervate droplets using a microfluidic channel structure allows for their use as cell‐mimicking compartments.
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