蛋白质-蛋白质相互作用
计算生物学
癌症
生物信息学
生物
生物化学
遗传学
作者
Shilpa Sharma,T M Ramsey,K W Bair
出处
期刊:Current medicinal chemistry
[Bentham Science]
日期:2002-03-01
卷期号:2 (2): 311-330
被引量:33
标识
DOI:10.2174/1568011023354191
摘要
Protein-Protein (P-P) interactions play a pivotal role in determining cellular structure and in all cellular processes. The nature of P-P interactions is complex, and despite the large amount of research that has occurred in the field, is still poorly understood. Abnormal P-P interactions are particularly important because of their association with a variety of diseases, including cancer. This review examines P-P interactions with particular emphasis on the discovery of new anti-tumor drugs, including underlying physical forces that determine affinity and specificity and discusses classical and newer strategies used to discover inhibitors of P-P interactions, providing a number of recent cancer-related case studies and commentary.
科研通智能强力驱动
Strongly Powered by AbleSci AI