医学
斑秃
甲状腺过氧化物酶
亚临床感染
门诊部
抗甲状腺自身抗体
甲状腺
甲状腺功能
内科学
甲状腺功能测试
甲状腺疾病
甲状腺球蛋白
自身免疫
自身抗体
胃肠病学
内分泌学
皮肤病科
免疫学
抗体
疾病
作者
Ola Ahmed Bakry,Mohamed Basha,Maather Kamel El Shafiee,Wafaa Ahmed Shehata
标识
DOI:10.4103/0019-5154.123494
摘要
Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The etiopathogenesis of the disease is still unclear, but the role of autoimmunity is strongly suggested. AA is commonly associated with various autoimmune disorders; the most frequent among them is autoimmune thyroid disorders.To determine whether AA is associated with thyroid autoimmunity or thyroid function abnormalities in Egyptian patients.Fifty subjects with AA (37 males and 13 females) without clinical evidence of thyroid disorders were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital, Menoufiya Governorate, Egypt, during the period from June 2009 to February 2010. They were divided into 3 groups according to severity of AA. Fifty age and sex-matched healthy volunteers (35 males and 15 females) were selected as a control group. Every case and control were subjected to history taking, complete general and dermatological examination. Venous blood samples were taken from cases and controls after taking their consents for measurement of thyroid stimulating hormone (TSH), free T3, freeT4 and detection of Anti-thyroglobulin Antibody (Tg-Ab) and Anti-thyroid Peroxidase Antibody (TPO-Ab).Subclinical hypothyroidism was detected in 16% of cases. There were statistically significant differences between cases and controls regarding levels of TSH, free T3 and free T4. There were significant differences between cases and controls regarding the presence of Tg-Ab and TPO-Ab.Every patient with AA should be screened for thyroid functions and presence of thyroid autoantibodies even in absence of clinical manifestations suggestive of thyroid affection.
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